The star has given the entirety of his £25k honor prize money to the MVT, which functions to preserve the Britain's grassroots live music spots.
He was awarded the award on mid-October as his third album his work was named the best record of the past year.
Fender has decided to hand the money over to the trust, in appreciation of the essential function small stages fulfilled in his initial steps.
"I personally would not have achieved my current career if it weren't for all the gigs I performed around the North East, and further afield, when I was beginning," remarked Sam Fender. "These venues are renowned, but they are in difficulty."
Beginning in 2023, at least 150 of these spaces have ceased operations – about one-sixth of the whole industry in the UK.
Over the past year, top acts including the band Pulp, the group Coldplay, Katy Perry and Ed Sheeran have all backed the Music Venues Trust in its initiatives to help venues survive, by including a small levy to their ticket prices, which supports smaller concert halls.
Fender also took part, raising more than £100,000 on his live tour to help numerous grassroots venues across Britain.
These funds supported spaces that were confronting potential shutdown due to issues arising from water damage, fire incidents and family tragedies, as well as regulatory hurdles, conflicts and neighbor objections.
Some locations were granted funding support in modernizing facilities and sound and lighting systems that positively impacted performers and concertgoers.
"The notion that revenue from shows in major spaces backs the local stages, where it all starts for musicians like me, is just logical," Fender has said.
Fender is among several artists to give his Mercury Prize prize money to good deeds.
When the band earned the award in the year 1996 for their record Different Class, lead singer Cocker stated that the group would contribute their cash to the non-profit the charity.
That year, rapper and singer Ms Dynamite split her prize across multiple organizations, like the NSPCC and a Sickle Cell charity.
"Additionally, I gave a £1,000 to the center, to their classes, because I did gymnastics when I was growing up and they lacked updated gear," the artist told outlets.
Previously, the band gave their winnings to the youth organization that developed their act, in addition to other independent music bodies.
And winners that year M People gave their award to a charity for MS after a close contact was identified with the illness.
"Winning was ample," stated singer Heather Small. "The cash was the extra but we didn't need the extra, because we had the main prize. So our winning impacted the lives of others."
In the past week, the MVT announced it had protected a couple of local spots in that region, by bringing them into community ownership.
One venue in the city and the other in Bristol were purchased under the Own Our Venues initiative, which is supported by Arts Council England and music fans who buy "shares" in the venues.